The development and clinical adoption of quantitative imaging biomarkers (radiomics) has established the need for the identification of parameters altering radiomics reproducibility. The aim of this study was to assess the impact of magnetic field strength on magnetic resonance imaging (MRI) radiomics features in neuroradiology clinical practice.
T1 3D SPGR sequence was acquired on two phantoms and 10 healthy volunteers with two clinical MR devices from the same manufacturer using two different magnetic fields (1.5 and 3T). Phantoms varied in terms of gadolinium concentrations and textural heterogeneity. 27 regions of interest were segmented (phantom 21, volunteers 6) using the LIFEX software. 34 features were analyzed.
In the phantom dataset, 10 (67%) out of 15 radiomics features were significantly different when measured at 1.5T or 3T (student's t-test, p &lt; 0.05). Gray levels resampling, and pixel size also influence part of texture features. These findings were validated in healthy volunteers.
According to daily used protocols for clinical examinations, radiomic features extracted on 1.5T should not be used interchangeably with 3T when evaluating texture features. Such confounding factor should be adjusted when adapting the results of a study to a different platform, or when designing a multicentric trial.
According to daily used protocols for clinical examinations, radiomic features extracted on 1.5T should not be used interchangeably with 3T when evaluating texture features. Such confounding factor should be adjusted when adapting the results of a study to a different platform, or when designing a multicentric trial.Management of locally recurrent rectal cancer (LRRC) after surgery or external beam radiotherapy (EBRT) remains a clinical challenge, given the limited treatment options and unsatisfactory outcomes. This study aimed to assess long-term outcomes of computed tomography (CT)-guided radioactive I seed implantation in patients with LRRC and associated prognostic factors.
A total of 101 patients with LRRC treated with CT-guided I seed implantation from October 2003 to April 2019 were retrospectively studied. Treatment procedures involved preoperative planning design, I seed implantation, and postoperative dose evaluation. We evaluated the therapeutic efficacy, adverse effects, local control (LC) time, and overall survival (OS) time.
All the patients had previously undergone surgery or EBRT. The median age of patients was 59 (range, 31-81) years old. The median follow-up time was 20.5 (range, 0.89-125.8) months. The median LC and OS time were 10 (95% confidence interval (CI) 8.5-11.5) and 20.8 (95% CI 18 previously underwent EBRT or surgery. Dand GTV significantly influenced prognosis of such patients.
CT-guided 125I seed implantation is a safe and effective salvage treatment for LRRC patients who previously underwent EBRT or surgery. D90 and GTV significantly influenced prognosis of such patients.Radiotherapy (RT) is the primary treatment option for nasopharyngeal carcinoma (NPC), but it is associated with radiation-induced sarcomas (RISs). This study aims to investigate clinicopathological features and head and neck RIS prognosis after NPC RT.
The medical and radiological records of the NPC patients (n =14,074) referred to Zhejiang Cancer Hospital, Hang Zhou, China between January 1995 and December 2018 were retrospectively reviewed. Among them, 22 patients were determined to have RIS after RT for NPC. The clinicopathological data, diagnosis, treatment, and follow-up results of 22 patients with RIS were analyzed in this retrospective research. All 22 patients underwent surgery as the main treatment. The levels of Overall Survival (OS) were determined through the Log-rank test and Kaplan-Meier method.
Among these patients, 13 were males and nine females with the male/female ratio of 1.441. The age during the primary RT of NPC ranged from 25 to 61 years old (median age 37 years old). Patients' agimary and optimal choice for the treatment of RIS.
Although the incidence of RIS after RT of NPC is generally low, the treatment of RIS is very difficult. The RISs are associated with poor overall prognosis. R0 resection can improve the prognosis thus it should be considered as the primary and optimal choice for the treatment of RIS.Thirty-two Head and Neck cancer patients were operated by surgical team of the Indian Institute of Head and Neck Oncology (IIHNO) in a period ranging from May 2020 to the first week of December 2020. Surgical procedures ranged from surgery for tongue cancer, resection of cancers of the oral mucosa/cheek (with or without reconstruction), as well as surgery for paranasal cancers and thyroid cancers, with an average duration of 3 h for the procedures. This article reviews this experience during the peak of covid pandemic regarding the approaches adopted by the team of the IIHNO, a flagship project of the Indore Cancer Foundation, a public charitable trust.Ruminal disorders are a major threat to the health and welfare of animals worldwide especially in developing countries like Ethiopia. However, there is no recent published report on ruminal disorders and the possible management methods at veterinary clinics in Gondar town. https://www.selleckchem.com/btk.html The aim of this study was to identify the common ruminal disorders and treatments given to manage these disorders.
A retrospective study was carried out to identify the common ruminal disorders and their therapeutic management of ruminants (cattle, sheep and goat). Data on 127 cases of animals treated for ruminal disorders in three veterinary clinics were collected from case registration books. The data were analyzed using SPSS version 20 statistical software and descriptive statistics and nonparametric tests were used to analyze the data.
Ruminal disorders including simple indigestion, ruminal acidosis, free gas bloat and frothy bloat were identified. From these, 44.1% ruminal acidosis, 26% frothy bloat, 15.7% free gas bloat and 14.2y and feeding management are important to reduce the impact of ruminal disorders.
The findings had shown that ruminal disorders are the major challenges for livestock production in the study areas. Drug prescription without correct diagnosis was also observed. Therefore, accurate veterinary diagnosis and proper management of ruminal disorders as well as proper animal husbandry and feeding management are important to reduce the impact of ruminal disorders.